Evaluation of platelet indices in patients with nephrotic syndrome
Entry
Nephrotic syndrome (NS) proteinuria,
with hypoalbuminemia, hyperlipidemia, and edema
a common glomerular
is a disease. Complement in nephrotic syndrome
activation, circulating permeability
presence of factors, anti-inflammatory
benefit from treatments, NS
important role of inflammation in the pathogenesis of
It shows you playing.
1 Platelet
activation of markers in NS
variety that can be used to show
demonstrated in studies. thrombocytosis,
It is a common finding in NS.
in 2 NS
platelets are hyperagreable
shown.
3 Indicating inflammation
platelet markers, activation of NS and
guide in predicting the prognosis
it could be.
Mean platelet volume (MPV),
platelet distribution width (PDW),
platelet count (PCT), platelet count (PLT), and
platelet large-cell ratio (P-LCR)
indicates platelet activation and complete
automatically reported in the blood count.
4
MPV platelet volume, PDW circulating
shape differences in platelets, PCT is a
platelet count in unit blood volume
(marker showing total platelet volume)
and corresponds to hematocrit in erythrocytes)5
and P-LCR is normal for large platelets.
shows the ratio of platelets to platelets. Large
platelets are more reactive and dyslipidemia
to vaso-occlusive events in patients with
contributes.
6 In this study, thrombocyte
indexes as a marker in NS
determine whether to use
intended.
Methods
From January 2017 to January 2018
to the Pediatric Nephrology Outpatient Clinic in our center.
All patients followed up with the diagnosis of NS presenting
were included in the study (N=39). Study
Compliant with the Principles of the Declaration of Helsinki
It was performed as a clinic in our center.
by the Research Ethics Committee
approved. Studying patients with infections
was excluded. Hemoglobin (HGB), hematocrit
(HCT), Mean erythrocyte volume (MCV),
Red sphere distribution width (RDW), White
blood cells (WBC), PLT, MPV, PDW, PCT, PLCR, urea, creatinine, electrolytes, albumin,cholesterol, triglyceride, urinary findings
in relapses and remissions of the disease
obtained from the records. Working group
steroid-sensitive NS (SSNS) and steroid-sensitive
resistant NS (SRNS) into two groups.
Left. Patients in both groups relapsed
laboratory before treatment
values are compatible with both age and gender.
with the healthy control group as well as with each other.
were compared (N=30). In the SSNS group
values before and after steroid therapy
compared to steroid therapy
effect on platelet indices
researched.
Platelet indices hematological
on analyzer (Sysmax, XN-1000, SA-01, Japan)
using flow cytometric methods.
measured. Blood samples taken from patients
analyzed within hours. Platelets
methodological evaluation of the indexes
reference values as a result of problems
difficulties arise in determining
can come out.
7 With a healthy control group
this difficulty by comparing the patient group
has been eliminated.
Nephrotic syndrome diagnosis
hypoalbuminemia (albumin<2.5 g/dl),
nephrotic level proteinuria (40 mg/m2/h),
was placed in the presence of hyperlipidemia and edema.
Remission in nephrotic syndrome, urine <4
Proteinuria below mg/m2/hr or spot
urinary protein/creatinine ratio <0.2
defined as being. SSNS, 4-8 weeks
daily (2mg/kg/g) prednisolone
patient in remission after treatment
group, while the SRNS group
steroid therapy at the same dose at the same time
group of patients who did not go into remission after
was defined as. Renal biopsy 1-10
age, without hypertension,
normal kidney function and complement
good response to steroid therapy
minimal change disease
It was not made considering the pre-diagnosis. SRNS
kidney for all patients
biopsy was performed.
Statistical analysis
Normality of continuous measurements
controls were tested with the Shapiro Wilk test.
Control and individuals with nephrotic syndrome
for differences in continuous measurements
Student's t test was used. control, steroid
resistant and steroid-sensitive nephrotic
pertaining to continuous measurements in individuals with the syndrome
Variance analysis to detect differences
used. Homogeneity of variances
controls were tested with the Levene test and
differences between groups in homogeneous
Heterogeneous with One Way ANOVA test
Tested with the Welch test. Dual
For comparisons, the Bonferronni test and
Games-Howell tests were used. Descriptive
mean and standard as statistics
deviation values are given. Categorical
If the dependency between the variables is
Tested with the Pearson Chi-Square test.
Number and percentage as descriptive statistics
values are given. As statistical significance
p<0.05 was taken.
