Evaluation of platelet indices in patients with nephrotic syndrome

Entry

Nephrotic syndrome (NS) proteinuria,

with hypoalbuminemia, hyperlipidemia, and edema

a common glomerular

is a disease. Complement in nephrotic syndrome

activation, circulating permeability

presence of factors, anti-inflammatory

benefit from treatments, NS

important role of inflammation in the pathogenesis of

It shows you playing.

1 Platelet

activation of markers in NS

variety that can be used to show

demonstrated in studies. thrombocytosis,

It is a common finding in NS.

in 2 NS

platelets are hyperagreable

shown.

3 Indicating inflammation

platelet markers, activation of NS and

guide in predicting the prognosis

it could be.

Mean platelet volume (MPV),

platelet distribution width (PDW),

platelet count (PCT), platelet count (PLT), and

platelet large-cell ratio (P-LCR)

indicates platelet activation and complete

automatically reported in the blood count.

4

MPV platelet volume, PDW circulating

shape differences in platelets, PCT is a

platelet count in unit blood volume

(marker showing total platelet volume)

and corresponds to hematocrit in erythrocytes)5

and P-LCR is normal for large platelets.

shows the ratio of platelets to platelets. Large

platelets are more reactive and dyslipidemia

to vaso-occlusive events in patients with

contributes.

6 In this study, thrombocyte

indexes as a marker in NS

determine whether to use

intended.

Methods

From January 2017 to January 2018

to the Pediatric Nephrology Outpatient Clinic in our center.

All patients followed up with the diagnosis of NS presenting

were included in the study (N=39). Study

Compliant with the Principles of the Declaration of Helsinki

It was performed as a clinic in our center.

by the Research Ethics Committee

approved. Studying patients with infections

was excluded. Hemoglobin (HGB), hematocrit

(HCT), Mean erythrocyte volume (MCV),

Red sphere distribution width (RDW), White

blood cells (WBC), PLT, MPV, PDW, PCT, PLCR, urea, creatinine, electrolytes, albumin,cholesterol, triglyceride, urinary findings

in relapses and remissions of the disease

obtained from the records. Working group

steroid-sensitive NS (SSNS) and steroid-sensitive

resistant NS (SRNS) into two groups.

Left. Patients in both groups relapsed

laboratory before treatment

values ​​are compatible with both age and gender.

with the healthy control group as well as with each other.

were compared (N=30). In the SSNS group

values ​​before and after steroid therapy

compared to steroid therapy

effect on platelet indices

researched.

Platelet indices hematological

on analyzer (Sysmax, XN-1000, SA-01, Japan)

using flow cytometric methods.

measured. Blood samples taken from patients

analyzed within hours. Platelets

methodological evaluation of the indexes

reference values ​​as a result of problems

difficulties arise in determining

can come out.

7 With a healthy control group

this difficulty by comparing the patient group

has been eliminated.

Nephrotic syndrome diagnosis

hypoalbuminemia (albumin<2.5 g/dl),

nephrotic level proteinuria (40 mg/m2/h),

was placed in the presence of hyperlipidemia and edema.

Remission in nephrotic syndrome, urine <4

Proteinuria below mg/m2/hr or spot

urinary protein/creatinine ratio <0.2

defined as being. SSNS, 4-8 weeks

daily (2mg/kg/g) prednisolone

patient in remission after treatment

group, while the SRNS group

steroid therapy at the same dose at the same time

group of patients who did not go into remission after

was defined as. Renal biopsy 1-10

age, without hypertension,

normal kidney function and complement

good response to steroid therapy

minimal change disease

It was not made considering the pre-diagnosis. SRNS

kidney for all patients

biopsy was performed.

Statistical analysis

Normality of continuous measurements

controls were tested with the Shapiro Wilk test.

Control and individuals with nephrotic syndrome

for differences in continuous measurements

Student's t test was used. control, steroid

resistant and steroid-sensitive nephrotic

pertaining to continuous measurements in individuals with the syndrome

Variance analysis to detect differences

used. Homogeneity of variances

controls were tested with the Levene test and

differences between groups in homogeneous

Heterogeneous with One Way ANOVA test

Tested with the Welch test. Dual

For comparisons, the Bonferronni test and

Games-Howell tests were used. Descriptive

mean and standard as statistics

deviation values ​​are given. Categorical

If the dependency between the variables is

Tested with the Pearson Chi-Square test.

Number and percentage as descriptive statistics

values ​​are given. As statistical significance

p<0.05 was taken.