What is poliomyelitis??đ¤ˇââ
đ´đ´Poliomyelitis is an acute viral infection caused by an RNA virus which is primarily an infection of the human alimentary tract but the virus may infect the central nervous system in a very small percentage(1%) of cases in varying degrees of paralysis and possibly deathđ´đ´
āĻāĻŦāĻžāĻ° āĻāĻ¸āĻŋ Polio āĻāĻ° Epidemiology āĻ¨āĻŋā§ā§đđ
đˇAgent factors:
âŦAgent:Poliovirus(It is an RNA enterovirus)
âŦReservoir of infection:Man is the only known reservoir of infection.Most infections are subclinical.
âŦInfectious material:Faeces & oropharyngeal secretions of an infected person
âŦPeriod of communicability :7-10days
đˇHost factors:
âžAge:Occurs in all age group but children are more susceptible than adults
âžSex:Male:female=3:1
âžRisk factors:
đTrauma
đFatigue
đIntramuscular injection
đOperative procedures such as tonsillectomy
đˇEnvironmental factors:
âžSeason:more in rainy season
âžContaminated water,food,and flies and overcrowding are important contributory factors
đˇMode of transmission :
âžFaeco-oral route:Main route of spread in developing countries
âžDroplet infection:More important during epidemic and where sanitation is good(developed countries)
đˇIncubation period:7-14days(Range 3-35days)
āĻāĻŦāĻžāĻ° āĻā§āĻ¨ā§ āĻ¨ā§āĻ "CLINICAL SPRECTRUM OF POLIO"đđ
1âŖIn-apparant polio/Subclinical infection:
đ¸This occurs in 91-96%of infections
đ¸No sign & symptom
đ¸Virus can be isolated from stool
đ¸Rising antibody titre
2âŖAbortive polio/minor illness:
đ¸This occurs in 4-8% infections
đ¸Mild or self-limiting illness due to viraemia
đ¸Patient recovers quickly
đ¸Diagnosis can't be made clinically
đ¸Virus can be isolated from stool
đ¸Rising antibody titre
3âŖNon-paralytic polio:
đ¸1%infection
đ¸Sign & symptom-stiffness and pain in the neck and back
đ¸Disease last for 2-10days.Recovery is rapid.
đ¸Similar to aseptic meningitis
4âŖParalytic polio:
đ¸Occurs in <1% of infections
đ¸Invades CNS & causes asymmetrical flaccid type of paralysis
đ¸A history of fever at the time of onset of paralysis is suggestive of polio
5âŖOther associated symptoms:
đ¸Malaise
đ¸Constipation
đ¸Anorexia
đ¸Abdominal pain
đ¸Nausea
đ¸Headache
đ¸Sore throat
āĻāĻāĻ¨ āĻāĻ¸āĻŋ āĻā§āĻāĻžāĻŦā§ Polio āĻā§ Prevent āĻāĻ°āĻž āĻ¯āĻžā§đđ
Immunization is the sole effective means of preventing poliomyelitis.āĻāĻāĻ¨ā§āĻ¯ ā§¨āĻ§āĻ°āĻ¨ā§āĻ° vaccine āĻŦā§āĻ¯āĻŦāĻšāĻžāĻ° āĻāĻ°āĻž āĻšā§ā§ āĻĨāĻžāĻā§âĄ
1âŖInactivated(Salk) polio vaccine (IPV)
2âŖOral(Sabin) polio vaccine(OPV)
āĻāĻĻā§āĻ° Dose schedule āĻšāĻ˛âĄ
đ´OPV:total 3dose āĻ¯ā§āĻā§āĻ˛āĻž 4week interval āĻ 6,10,14 week āĻ āĻĻāĻŋāĻ¤ā§ āĻšāĻŦā§ ā§¨āĻĄā§āĻ°āĻĒ āĻāĻ°ā§
IPV:total 2dose āĻ¯ā§āĻā§āĻ˛āĻž 8week interval āĻ 6,14week āĻ āĻĻāĻŋāĻ¤ā§ āĻšāĻŦā§ .1ml āĻāĻ°ā§đ´
āĻāĻĻā§āĻ° āĻŽāĻ§ā§āĻ¯ā§ āĻĒāĻžāĻ°ā§āĻĨāĻā§āĻ¯ āĻāĻžāĻ¨āĻ¤ā§ āĻ¨āĻŋāĻā§āĻ° ā§§āĻ¨āĻ āĻāĻŦāĻŋ āĻĻā§āĻā§āĻ¨đ
āĻā§āĻļāĻŋāĻ° āĻāĻĨāĻž āĻšāĻā§āĻā§ Polio āĻā§ eradicate āĻāĻ°āĻž āĻ¯āĻžā§đ¤āĻ¤āĻžāĻšāĻ˛ā§ āĻā§āĻ¨ā§ āĻ¨ā§āĻ āĻā§āĻ¨ āĻāĻ°āĻž āĻ¯āĻžā§ đ¤ˇââđ
â Man is the only host
â No long term carrier state
â OPV is cheap & easy to administer
â Half-life of excreted virus is 48hours & spread can only occur during this period
â Live attenuated viruses in OPV multipy in intestine & interrupt the transmission of the wild viruses
â OPV induces both humoral & intestinal immunity
â Antibody is quickly produced
â Viruses can be transmitted from a recently vaccinated child to close contacts who have not immunized
â No insect,vector,animal is involved in the transmission of disease
â Having international cooperation(NID)