THCO Acetate Distillate production is remarkably similar to heroin production from morphine. By adding an acetate group to a compound, its bioavailability and efficacy can be improved. THC-O shares a structural basis with naturally occurring cannabinoids, but its functional acetate group does not.
Multiple extractions from industrial hemp are required to produce THC-O. Cannabidiol (CBD) is derived from hemp, and then delta-8 is derived from CBD. At this stage, they add acetic anhydride, an extremely flammable compound, to the mix to create THCO Acetate Distillate. In its ideal form, it has the consistency of motor oil and is a dark brown color.
Making tetrahydrocannabinol-O-acetate is an extremely dangerous process. Its production requires a vacuum hood, so you shouldn't do it just anywhere. Only those who are well-versed in the subject matter and possess the necessary tools should attempt to do so. To produce THCO Distillate, highly reactive, combustible, and toxic chemicals are used.
One part of the process involves refluxing in strong acid. During heating, a strong vacuum is required in the flasks. It is a necessary step, but one that could lead to an implosion. If such an incident occurs, the emission of glass, boiling acid, flammable liquids, and poisonous vapor could prove fatal.
Making THC-O also involves causing an off-gassing of peroxide gas into the air. It is explosive, so a single spark could result in an explosion. NEVER try to make THC-O at home!
Yes. It is approximately three times stronger than THC. It takes a surprisingly small amount to trigger hallucinatory effects. THC-O is a prodrug. This means it doesn’t become active until after the liver metabolizes it. Once the drug is metabolized, what’s left is D9.
One of the reasons why THCO Distillate is so strong is due to its high rate of bioavailability. THCO Acetate Distillate is far more bioavailable than its delta-9 counterpart. Its functional group (-O) is removed after absorption. Consequently, THC has its usual effects but at a substantially higher dose. Yet, as strong as THC-O is, it is not quite as potent as THCP.
It depends on the method of consumption. Even though it is a relatively new market, you can purchase:
THC-O vape liquid
First of all, please remember that it is triple the strength of “standard” THC. Therefore, you should use one-third of what you would normally consume in a delta-9-THC product.
If smoking or vaping THCO Distillate, stick to a dosage of up to 0.5mg. When using it via oil or edibles, up to 3mg is sufficient. Going beyond these levels will probably result in intoxication. If you smoke over 5mg or orally consume over 10mg, you will likely experience psychedelic effects, which could prove unpleasant or even frightening. It is also best if novices steer clear of THC-O entirely.
At present, there is no formal research data available on cannabinoids. However, THCO Acetate Distillate reviews from consumers suggest it could help manage pain, boost appetite, and reduce anxiety. High doses of it could prove incapacitating, and some users compare its effects to those produced by low levels of mescaline.
As it is a prodrug, the effects can take up to 30 minutes to kick in. During that time, it is essential not to take a second dose. If you use an edible, you might not feel anything for a couple of hours. It offers a heavy, physically sedating effect that can last for several hours for most users. Also, the visual experience is far beyond what you’ll experience with D9.
At present, there are no available scientific studies on the safety of THC-O. It is almost certainly safer than other synthetic cannabinoids such as Spice, which is a non-classical cannabinoid. This means it activates the same receptors as THC and other cannabinoids but doesn’t have a similar chemical structure, unlike THCO Distillate.
Apart from the lack of research, there is a small matter of the market’s unregulated nature. In October 2021, NORML published a report highlighting the dangers of unregulated delta-8, delta-9, and THCO Distillate products. The report urged people not to purchase such items and warned of exposure to an artificially concentrated terpene level in some products that could have toxic effects when inhaled.