I tell you that spokesmen for the famous Recovery Trial clinical study, which are dedicated to seeking possible treatment for covid-19 in the United Kingdom, released the results of one of their studies that talks about the use of a drug that can reduce the deaths from coronavirus in the world: the well-known DEXAMETASONE.
This new scientific advance is really a victory in the global fight against the covid-19 pandemic, and these researchers affirm that it is not a cure, but a drug that can increase the life expectancy of a patient who is presenting symptoms. serious.
As everyone knows, DEXAMETASONE is a drug that is widely used in different medical specialties, which belongs to a group of steroids with potential anti-inflammatory effects and is indicated to stop those inflammatory processes produced by viruses, bacteria or trauma of any other type. Also to treat serious allergic reactions such as rhinitis and urticarias, to reduce inflammation in the bronchi of asthmatic patients, to stop brain inflammations of different origins and to treat autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis in the initial stages.
This drug is classified as an intermediate-acting steroid, which means that its anti-inflammatory effect works quickly and lasts between 12 and 18 hours. If at the end of those hours the inflammation stopped, the drug can be suspended, but if it continues, it should be used again, "said Maldonado.
The aforementioned internist added that other steroids also have longer effects that can range from three to six days, which is why he stated that doctors indicate this drug when they need to monitor the anti-inflammatory reaction.
Now, what are the presentations and warnings for the use of DEXAMETASONE?
This drug is available in tablets, injections and syrups, mainly for pediatric use, but the doses must be determined by a specialized doctor. He clarified that this or any other drug should be self-medicated.
He stressed that people with diabetes and high blood pressure could have complications after the use of dexamethasone, so the treating doctor must know if the patient has pre-existing diseases before indicating it.
Both this and all steroids increase blood glucose levels (amount of sugar in the blood), that is, a patient with low levels may rise a little, but another with levels of 500 may have serious complications, "said the specialist.
Those with high blood pressure who use this drug begin to retain fluids, which thickens the blood and can cause chest pain, angina pectoris, hypertensive crisis and even trigger a heart attack.
Use in treatment for coronavirus
Internist Alexis Maldonado pointed out that viral processes such as the coronavirus produce inflammations in the body. He added that inflammation is a cellular and biochemical process that releases substances that affect organs such as the lungs.
Dexamethasone, explains the specialist, acts on two levels on the immunity of cells and on the immunity of substances, thus slowing down inflammation.
In this sense, Maldonado suggests that between March and April the use of dexamethasone in patients with covid-19 was very common, because it was used to reduce inflation in the bronchi and shows an improvement in the lungs. However, he clarified that it has no antiviral effect.
The Recovery Trial researchers stated that in the UK clinical trial, they required ventilator-assisted respiration and received a daily dose of 6 mg of dexamethasone for 10 days showed improvements. However, for those who could breathe normally, there was no benefit. That is a result that is statistically very significant.
Finally, the preliminary result was that the treatment reduced the risk of death by a third in the critically ill patients who participated in the study.
On the other hand, Peter Horby, who is a researcher and head of the Recovery Trial and professor at the University of Oxford, pointed out that dexamethasone was chosen for this research, because it is a drug that showed a good response in other viral respiratory infections, it is also low cost, easy to find and world renowned.
Now, I emphasize through this post that the full report of the results has already been published, so that medical authorities in the United Kingdom have started the treatment with confidence and make it a global standard to treat patients with coronavirus in serious condition.
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