Good morning to all, how are you? Me, nothing's changed, still the same, lol, hope you will like this article of mine here again, somehow, i guess, some can relate to this one again as it might happened or occured or had inherit this type of disorder to their parent or parents and also somehow find this article of mine to be informative and helpful at the same time, lol, so let's start.

What's Genetic Disorder?

It's a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence.

It can be caused by a mutation in one gene or the so-called Monogenetic Disorder, by mutations in multiple genes or Multifactorial Inheritance Disorder, by a combination of gene mutations and environmental factors, or by damage to chromosomes or change in the number or structure of entire chromosomes, the structures that carry genes.

It's a disease caused by an abnormality in the genetic makeup IQ of an individual.

It can be inherit from the Parents while acquired changes or mutations in a pre-existing gene or group of genes cause other genetic diseases.

It can occur either randomly or due to some environmental exposure.

      4 Kinds Of Inherited Genetic Disorders

Single Gene- also called as Mendelian or Monogenetic Inheritance. It's a change or mutations that occur in the DNA sequence of a single gene.

                               10 Types

1. Autosomal Dominant- only one copy of a defective gene(from either Parent) is necessary to cause the condition.

2. Autosomal Recessive- a two copies of a defective gene(one from each Parent) are necessary to cause the condition.

3. X-Linked- the defective gene is present on the Female or X-Chromosome. It can be dominant or recessive.

4. Cystic Fibrosis

5. Alpha and Beta-Thalassemias

6. Sickle Cell Anemia or Sickle Cell Disease

7. Marfan Syndrome

8. Fragile Syndrome

9. Huntington's Disease

10. Hemochromatosis

Multifactorial- also called as Complex or Polygenic, caused by a combination of environmental factors and mutations in multiple genes, also associated with heritable traits such as Fingerprint Patterns, Height, Eye Color and Skin Color. May also occur because of Chromosomal Translocation in which portions of 2 chromosomes are exchanged.

                             7 Examples

1. Heart Disease

2. Highblood Pressure

3. Alzheimer's Disease

4. Arthritis

5. Diabetes

6. Cancer

7. Obesity

Chromosome Abnormalities- typically occur due to a problem with cell division.

                                5 Kinds

1. Down Syndrome

   7 Symptoms and Signs

   1. A small head short neck.

   2. Flat face

   3. Upward slanting eyes, ears are flat and positioned lower than normal

   4. The tongue protrudes and seems to be too large for the mouth

   5. Hands tend to be wide

   6. Short fingers and there is just a single flexion crease in the palm

   7. Joint tend to be more flexible and muscles may lack tone

2. Trisomy 21 or a common Genetic Disorder that occurs when a person has 3 copies of chromosome 21.

3. Turner Syndrome

4. Klinefelter Syndrome

5. Cri Du Chat Syndrome or the Cry of the Cat Syndrome

Mitochondrial- caused by mutations in the non-nuclear DNA of Mitochondria, always inherited from the Female Parent.

                                Examples        

1. Leber's Hereditary Optic Atrophy(LHON)- an eye disease

2. Myoclonic Epilepsy with Ragged Red Fibers or MERRF

3. Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like Episodes or MELAS, a rare form of Dementia

   4 Complex Pattern of Inheritance Disease

1. Diabetes

2. Asthma

3. Cancer

4. Mental illness

Good morning and good night, tomorrow again, hope you really like this one, lol, have a good day :)