Worldwide, the use of vaccines is seen as critical for the prevention and control of many economicallydamaging outbreaks of poultry diseases. In Caribbeancountries, the use of vaccination to prevent poultry diseases is variable and is mainly influenced by the size of the poultry industry in the various countries. Many of the larger poultry-producing CARICOM countries (for example, T & T, Jamaica, Belize, Barbados, and Guyana) with large poultry (broiler and layer) operations have structured and rigid regimes of vaccination in place, while smaller island states (for example, Grenada and St. Lucia), with smaller poultry and egg production operations, often do not vaccinate their poultry. The larger intensive broiler and layer production units in the Caribbean routinely vaccinatetheir birds against IBV, NDV, and IBDV, whereas somesmaller semi-intensive and backyard operations oftendo not carry out vaccination against these three viralpathogens. Routine vaccination is not carried out in theregion against other viral pathogens (AIV, ILTV, APV,FADV Gp1, and EDSV) included in this review,although occasional vaccination against FADV Gp1has been carried out in the face of disease outbreaks. All reports/publications describing the detection of viruses and outbreaks of disease in both vaccinated andunvaccinated poultry were reviewed. Wheninformation pertaining to vaccination history wasgiven in the relevant report/publication, thisinformation was included.