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Former world number one Serena Williams withdrew from the US Open next week and said her hamstring tear had not fully healed before the last Major of the year.
American is the six-time Flushing Meadows champion. This season, he suffered injuries and a leg injury. He limped out of his first round at Wimbledon.
The 39-year-old has been looking for an elusive 24th Grand Slam. He skipped the Tokyo Olympics and opted out of the Cincinnati Masters, a US Open tuning event. After defending men's champion Austrian Dominic Tim and four-time champion Rafa Nadal ended their 2021 season due to injury.
Williams is the latest big-name player to withdraw from the tournament.
U.S Open will take place in New York on Monday.