Who are some actors/actresses who took a break from acting and their career never recovered?

This should be subjective.

Majority of talent who takes a break is able to return and re-climb the ever-changing rotation of A list. 6 months, people. That’s A-List.

I just watched a show on Shelly Long. Emmy winning actress whose run from the 70s (MASH) to the 80s (Cheers) was unmatched. Today she’s barely recognizable in tabloid pics and seems happier than ever with her life off-camera.