Microbiota - Probiotics: what are these ?
Probiotics were originally introduced as the opposite of antibiotics, living microorganisms consumed to restore the microbiota that we lost after antibiotic treatments. A probiotic is a living microorganism which provide a health benefit to the host and promote gut health when administered in adequate amounts. A probiotic can strengthen the immune system, prevent infection with pathogens, compensate an unhealthy change in our microbiota or an infection by shortening the time of recovery for our microbiome, and even provide extra energy via more short chain fatty acids.
They provide hope in treating lactose intolerance, infections and post-antibiotic diarrhea, immunomodulation for allergies and chronic bowel inflammatory diseases. The biggest challenge is to make them to reach intestine alive, surviving the storage and the acidic medium of our stomach, and delivering the desired concentration in the end (which is strain dependent). We are aiming for 10 at the 7th colony forming units pre milliliter of product. Lactobacillus and bifidobacteria are the most used antibiotics.
Bifidobacterium
Tomorrow i will talk a bit about synbiotics. Have a nice day!
Yours truly
George
**P.S.** If you are Romanian, you can also publish your post link in the **Publish0x Romanian Community** Facebook group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - a quick word about prebiotics
What are the prebiotics, you would ask? They are fibres stimulating the microbial growth in the gut, when eaten, improving the gut health. These fibres can escape digestion in the small intestine, but once they reach the colon , they will be partially or completely fermented by the gut microbiota. The composition and the activity of the gut microbiota changes, because the microbes able to degrade those kind of fibres are favoured in their growth, and this is beneficial for the host (us).
Prebiotics fibres are made of oligosaccharides, chains of sugar molecules. The most known prebiotics are galactooligosaccharide (GOS), made of chains of galactose sugars and fructo-oligosaccharide (FOS) or inulin, made of fructose sugars. FOS and inulin can be found naturally in plants (onion, garlic, wheat, banana, chicory and various cereals). GOS are made by workers in dairy factories, converting lactose using beta-galactosidase enzymes. As they are digested by our microbiota, short chain fatty acids will be produced, and they will be used as an energy source, to reduce pain or influence the metabolism.
Prebiotics like GOS, FOS and inulin are very good to stimulate the growth of Bifidobacterium and Lactobacillus microbe species/ Both of them are commonly found in breast fed babies, and sometimes are added to the formula and infant milk to mimic the effect of breastmilk and increase Bifidobacterium and Lactobacillus in infant’s microbiota. They are also added to breakfast cereals, bars of cereals, cheese and custard. Apart from the microbiota fermentation product altering the host response, prebiotics can stimulate bowel movements and help with constipation, as they increase the stool weight, due to the prebiotic and the water attracted by the prebiotic.
Lactobacillus reuteri
Conclusion: Prebiotics are fibres that arrive in the colon intact. Here they are degraded, leading to the growth stimulation of the beneficial microbes in the gut. The microbial activity combined with the higher water content of the faeces will result in improved gastric health.
Next post will be about probiotics.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post link in the **Publish0x Romanian Community Facebook** group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
25.11.2020 - What is new in the Crypto-verse
First of all i have a surprise for all my readers, check my other post related to a NFT Giveaway, here is the link. Then, let's see what happened lately in the cryptomarket: https://www.publish0x.com/crypto-markets-and-marginal-gains/micronutrients-and-malnutrition-dietary-elements-summary-and-xpjdvmg
A digital painting of Ethereum main guy, Vitalik Buterin, just sold for 260 ETH (155.000 dollars today) on Async. The NFT is using a new technique called layering, remaking itself daily.
MEME project is selling 12 identical NFT, with one of them having hidden a whole wrapped Bitcoin worth around 19k dollars right now. The selling was dubbed a 'Rug Pull'as the WBTC will unlock once all of them are sold, with the value of the other 11 NFT crashing once the crypto is found.
Pickle Finance was hacked, with an innovative method using malicious jars to replace the real Pickle cDAI jar. Finally something different than the flash loan vector attack, showing to us that the best hackers are adapting as fast as the good ones are trying to find counter-measures to the latest hacks.
And, **buyers beware**, there is a fake UNISWAP application called Uniswap DEX, available on mobile phones. DO NOT USE IT! Or they will just stole your crypto.
Horizen, SAND and KEEP3R increased with 30-40%, and surprisingly Stellar and XRP got more than 50% increase. Verge, NANO and Stratis are also raising the market up, with 30-40% gains.
Ethereum 2.0 is apparently ready to go, after more than sixteen thousand validators choosed to stake 524288 ETH. It is about time to have faster, cheaper transactions on the ETH network. Let's see how this is rolling in! The interesting thing is that if ETH goes over $620, the next resistance levels are $784, $915 and $1200. Happy times.
Jeff Bezos's Venture Capital is now supporting a fintech startup called Chipper Cash, a company offering cryptocurrency trading in Africa. So, it is official, the Amazon guy is now into crypto.
If you are in America, Binance just send an email to their US users telling them that they have 14 days left to close their accounts.
Apparently the US department of justice has more than a billion dollars in BTC forks, associated with the seized assets from the darknet market Silk Road. They moved indeed the BTC, BCH and BSV, but there are few more forks that were not moved (Bitcoin Diamond, Super Bitcoin and Bitcoin Private, just to name a few)
Bad news for bad guys, Cipher Trace (a blockchain intelligence company) submitted patents for a technology able to track Monero coin. Monero (XMR) is a privacy coin used by many hackers and people trading illicit goods.
And to close our daily edition, a good news, this time for the people from China. Another digital yuan airdrop will start on 12th of December, in the Chinese city of Suzhou. The so-called Red Envelopes will be handed out on December 12 - an year end shopping festival day known as Double 12.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post link in the **Publish0x Romanian Community Facebook** group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - diagnosis and microbial therapies
We all should know that regarding us and our microbes, we work together to harvest the maximum of energy from our food and to fight against pathogens. But which is the best way to keep our microbiota healthy? Everybody heard, i hope, about prebiotics and probiotics. But anyway, i will try to explain a bit more. There are some fibers called prebiotics, that are beneficial to our microbiota. Also, there are some live cultures of microbes that can stimulate our gut health, once added to our diet. The composition of our microbiota can provide personal information about you, and can be used to develop personal food strategies. Our microbiota holds information that can help us to diagnose certain diseases too. So, while our microbes can tell about our health, they can be also used to improve our health and cure certain diseases. One example is the use of faecal transplant therapy to treat recurrent Clostridium difficile, with a bigger success rate than antibiotics and a lowest rate of recurrence.
Lactobacillus plantarum
I will do next a more indepth blog post about probiotics and prebiotics. See you soon!
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post link in the **Publish0x Romanian Community Facebook** group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - About being underweight and undernutrition
The term malnutrition refers to deficiencies, excesses or imbalances in a person intake or nutrients and energy and addresses to three groups of conditions:
1. Undernutrition
2. Micronutrient related malnutrition
3. Overweight.
1. Undernutrition - If you don't have enough nutrients, you are malnourished. It is not always the lack of food, but the lack of quality food. Undernutrition means that you have a shortage of calories and most often of essential nutrients (when the access to food is denied). This is a specific type of malnourishment. As a result, you are being underweight, wasted, growth is stunted, happening usually after a weight loss event such as infectious disease associated with diarrhea. Stunting means that a person has a low height for age, and it is the result of a long term undernutrition during childhood, holding the child back from achieving their physical and intellectual potential. being underweight is a child with a low weight for age, and you can also be stunted or wasted.
There are clear differences in the gut of the undernourished people compared with healthy individuals. Most of the researches on undernutrition are focused on children, because they need fast growth for their optimal development. Undernutrition in children can have long term health implications: reduced growth rate, immune and cognitive development.
In the same time, the gut microbiota of the undernourished children remains immature. But we do not know if this is a cause or a consequence. In a mice study, after transferring the gut microbiota of a malnourished infant donor, the mice will gain less weight than the ones receiving microbiota from a healthy donor. Undernourished infants often miss bacteria from Ruminococcus and Clostridium group. All those bacteria are the ones producing the short chain fatty acid called butyrate (which is an energy source for the host cells). The microbiota can contribute to the caloric value of your food. This is useful especially when food is scarce, and any part is needed as usable energy.
Ruminococcus bacteria
Another type of malnutrition is Anorexia Nervosa (which is characterized by distorted body image, extreme dieting and the anxiety of becoming obese as main underlying factors). All these symptoms will lead to severe weight loss. Even if it seems different that the undernourishment in children, the common element is the nutrient shortage. And similar changes are noticed in the composition of the microbiota. Anorexia patients will have lower amounts of total bacteria and obligate anaerobic bacteria. In addition, they will also have lower amounts of butyrate producing bacteria and higher amounts of mucin degrading bacteria.
I am doing at the moment a series of articles about malnutrition on my Publish0x blog, you can read it in there if you want to find more about it. https://www.publish0x.com/@Heruvim78
The undernutrition is affecting the microbiota and plays a role in the severity of the undernutrition by releasing less energy from food. The manipulation of the gut microbiota could be a helpful solution for undernourished children.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
So, i have this crazy idea of making a ful BCH just by writing in here. My first BCH. This is a worthy challenge. 0.05ready. 0.95 to go. Wish me luck! And a little yellow duck.
Microbiota and its role in becoming overweight
Our gut bacteria can be partially blamed for being overweight or obese. There is a causal link between the microbiota and obesity, driven in combination with overnutrition and drastic lifestyle changes.
The prevalence of obesity is reported to increase worldwide and it is a major challenge in our modern days. There are various attempts to explain the large increase in obesity, mostly due to the last three decades of research. They include calorie intake, changes in dietary composition, decrease in physical activity and changes in the gut microbiome. Is the gut microbiota contributing to the excessive weight accumulation in our body? A piece of evidence was published in 2005, when scientist found that obese mice microbiota composition is different from the healthy lean ones. An increase of Phylum Firmicutes bacteria was noticed in the obese mices, and their microbial diversity was lower than normal. This made them wonder if is obesity causing the changes in the microbiota or is the gut bacteria causing obesity? They got sample from human twins (one fat, one lean) and give them to germ free mice. The ones with bacteria from the slim ones stayed slim, the others quickly gained weight. So the conclusion was that there is a direct causal link between the gut microbiota and the weight gain. The next trials started with gut microbes from lean humans, given to obese individuals, and they improved their metabolic response and experienced weight loss. The effect lasted for few weeks when the study was done, but we do not know if the effect is sustained. Also, fecal transplant is prone to high risk of infection. We will talk later about this.
The gut microbiota is a major contributor to obesity. Our diet is another one, as the Western style diet is an example , characterized by highly processed and refined foods, rich in proteins and fats. It has a high salt, fat and sugar content, with protein mainly from red meat. This diet is the major contributor to the actual crysis of obesity and to a wide range of obesity related diseases. This type of diet leads to a low presence of Bacteroidetes and Akkermansia, followed by an increase in the firmicutes and proteobacteria groups. These alterations were associated with obesity and the subsecvent related chronic diseases. The high fat content causes an overload in energy leading to obesity, but the change in microbiota can also cause inflammation, which in turn can lead to many obesity related diseases.
Akkermansia
Diet can increase obesity and obesity related diseases directly and indirectly. The evidence supporting the link between obesity and lifestyle changes is very strong. Modulation of the microbiota might help to ameliorate metabolic responses and initial weight loss attempts. Adapting the microbiota might be useful to keep a healthy weight or even to lose weight.
Next post: Undernutrition and weight loss.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post link in the **Publish0x Romanian Community Facebook** group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - humans and animal intestinal flora similarities
There are clear differences between the genomes and diets of different species. Is there some evolutionary relationship of animal microbiota? There is indeed a definite difference between the genomes and diets of different animal species. Choosing the microbiome of the elephant, panda, python and few others for study, the microbiota of different animals will form clusters based of their evolutionary distance and dietary behaviour. We got herbivores, carnivores and omnivores. If we look for similarities based on the types of microbes and their abundance in the gut, then animals who are evolutionary close are also more alike on the microbiome level. But even for a big group like herbivores, there are clusters, based on whether the animal is a foregut or hindgut fermenter. Let me explain. A foregut fermenter has a fermenting chamber called rumen placed before the stomach. A hindgut fermenter has a fermenting chamber called cecum at the end of small intestine. Because they are different evolved digestive organs, they are selective for different microbes, hence the difference in the microbiota. The microbes are different based on the evolutionary relatedness of the host, but this clear separation dissapear when we consider the microbiota gene content. The gut microbial communities all share genes with similar functions, so even if the microbes are different, the functions executed are similar.
There was an experiment done, where zebra microbiota was transplanted to germ free mices. The microbes had to find a previous balance in their overall structure, adapting to the new host in the same time. The new environment forces the macrobiota to reach a new stable state. The new environmental conditions are determined by host genetics and lead to specific immune system and physiology, but they are also determined by the host dietary habits. There was another experiment where microbes where transferred from mices to germ free mice and from fish to germ free fish. The conclusion was that the host genetics is of major importance for the microbiota development. The mouse itself will adapt to the new microbiome using immune and metabolic adjustments.
Ruminococcus
So, the microbiome will adapt to its specific environment as the genetic make-up of the host and its dietary habits will determine the environmental conditions. Every animal species carry their own specific microbiota.
Next post : Microbiota and obesity. Now this will be an interesting one!
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Optimal use for Binance USD stablecoin.
So, i was testing different ways to get my Binance USD to work, and increase my portfolio. In case you need any introduction to it, BUSD is a stablecoin pegged to dollar, and can be used on Binance chain. The easiest option is Flexible Staking for 1.71% per year. But you can do better than that. Locked savings will pay 5.31% for 7 days, 5.48% for 14 days, 5.66% for 30 days and 6% for 3 months.
How did i do it? Lately Binance has working hard on their token launch platform for transformative projects, called Launchpad. They got different pools where you can use some native tokens, BNB and BUSD. Their latest third projects were Certik (CTK), Hard Protocol HARD) and Unifi Protocol DAO (UNFI).
What was the annualized yield on each?
Certik (CTK) - **7.92% closed now**. CertiK's Decentralized Security Oracle claims to audit, guard on-chain transactions and prevent malicious actors to hack a project using real-time security checks. Certik was one of the three enterprises who did an audit on Harvest finance, but if i am correct, they did not finished the audit at the time of FARM hack.
Hard Protocol (HARD) - **4.87%** as per 20.11.2020. Kava project was testing a new approach, with the introduction of the HARD Protocol, the world’s first cross-chain money market. What that means? Just a fancy word for another DEFI project, where you can lend, borrow and be rewarded with the governance token of the application, HARD. the initial assets used by the HARD protocol are BTC, BNB, BUSD, USDX, XRP, and HARD. It is mainly supported by KAVA and Binance.
Unifi Protocol DAO (UNFI) - **5.52%** as per 20.11.2020. This token is available across multiple blockchains, and is a solution for DEFI market, using smart-contract . Unifi Protocol DAO is a group of non-custodial, interoperable, decentralized, and multi-chain smart contracts hoping to create the premises for the next layer of decentralized finance. UNFI token holders will earn Staking Rewards for staking their UNFI tokens, with the possibility to get even more rewards from their chosen community rewards after you delegate your staked UNFI. The supply is quite small, only 10 millions. They aim to be present on the following blockchains: Binance, Polkadot, EOS, Algorand, OmiseGo, ælf, Kyber, Wax, Zilliqa and Tomochain.
Which is not bad overall, given that the tokens from the Launchpad tends to increase in value over time. A good strategy will be to collect them and sell them right before the mainnet launch, when usually they are all time high (most of the cases, but not all of them). Or you can just HODL.
Another alternative is to move your BUSD on Celsius.network app, for **10.51%** annualized yield (or **13.86 %** maximum yield if you have more than 20% of your portfolio in CEL token and choose to be rewarded in CEL).
So, the winner is Celsius app, having the maximum yield with a set and forget strategy, you deposit your BUSD there and after that you just wait for rewards every Monday.
**Fun fact: Today you need 86.500 BUSD to get paid 1000 dollars per month in rewards.**
What are your other options?
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - relationship between diet and genes (twins and siblings)
Your genetic makeup is an important factor determining what your microbiota looks like. Let’s explore the close relationship between diet and genes.
The example used is the one of two twins, whom are genetically identical. However, their microbiome is not identical, due to the different environmental factors that they were exposed. Twin number one doesn’t like veggies, and twin number two is vegan. They also have a sister who can eat everything. She is genetically different that the twins, so if we compare the twins with her, their microbiome becomes very similar, but if we compare the sister microbiome with other people outside her family, all three of the siblings share more similarities. The reasons behind this observation lays within their genes and their shared environment. They are born by the same mother and they are often eating same food.
F. prausnitzii
Looking even wider, they share common similarities with the whole human race, compared with the rest of the animals. The genetic background is a very important co-founder for microbiota composition, influencing the elusive relationship between your own microbes and the diet. The way of how each host microbes evolved in case of humans is clearly distinct from that of other animals. Even the genetic differences between different human beings influences the microbiota composition.
In conclusion, the transmission of our microbiota and the establishment of a stable microbiota depends on environment, genetic information and diet (eating habits).
Next post: Microbiota — about mice and men
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - Communities and similarities
The human gut microbiota is different in all the humans being worldwide, so your microbiota is like your personal fingerprint. However, there are many similarities between different microbiota, and this information can be used by us to develop health biomarkers and to define therapeutic strategies.
The human gut consists in trillions of microbes and the whole ecosystem varies between individuals in diversity, distribution and abundance. In any ecosystem the selective pressures, disturbances and survival conditions are very important in defining the species leading to a distinct community type in that area. There was a study on human microbiome investigating the impact of possible steering factors such as the dietary habits. The observation underlines that certain combination of microbes, distribution and diversity can lead to a distinct community structure. But, even more important, the people can be grouped in 3 main groups, in a similar way to the blood group type. They can have a high number of Bacteroides, Prevotella or Ruminococcus. People eating a diet with less fibre and high in animal fat tend to have the Bacteroides community, people with a diet high in fibre and low in animal fat tend to have Prevotella community type and finally, was shown that every individual will have a gradient from high to low abundances on these three groups of bacteria. You can see that different dietary habits can support different microbes, and changes to diet can shift the percentage of each community type.
Ruminococcus bacteria
There is also the concept of the genes present in the microbial complex, which will define the potential of degrading complex fibres. So now the community type will also include this microbial gene into information. It turned out that some of us have high gene richness and others can have low gene richness. This low and high gene count can be used to separate individuals in a population. If you got inflammatory bowel disorder and obesity, you will usually have low gene richness. You are also more likely to get more weight than someone with high gene richness. All these concepts can be used to predict individual susceptibility to gain weight.
Even if the individual microbiota is different for each person, there are characteristics that are overlapping. Knowing how a community will respond to a diet and other pressures helps to develop health biomarkers and therapies.
Next post will be about twins and siblings microbiota.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Promo-codes for free money on Celsius network
There are few more codes for Celsius emerging these days. https://celsius.network/download-app/?_branch_match_id=786176267473301667
If you deposit for the first time, there are quite few 20$ Promo-codes:
**Gold20**
**Bethefuture**
**Fall20**
**Start**
There is an additional one if you deposit $100+ in Ethereum Classic:
**ETClabs**
I used this last one and worked for me.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - About dietary types
Today we will talk today about dietary habits. We all know that our diet determine what our microbiota can feed off. So, knowing this, we can change our microbiota changing our diet.
How can we do that? Easy, but you need to learn about it. You want to lose weight, you will use a calorie deficit diet, and once you reached the desired weight, you stop. This move will have a drastic effect on your microbiota, but as soon as your eating habits are back to normal, your microbiota will regulate too, because it developed a stable state over the years, and that it is not easily disturbed.
I have read about an interesting study, where they switched the diets of a population of African-Americans with that of the rural Africans. The African-Americans were given a high fibre, low fat African style diet. The rural Africans were given high fat, low fibre Western style diet. After a while, the African style diet was shown to support beneficial microbes and improved function, the Western style diet increased the risk of cancer. This research shows how short dietary changes can affect our microbiome and health.
In order to understand the long term effects of dietary habits, the researchers studied a number of individuals from different countries. People from Western world with a diet of high protein and low fibre content tend to have more Bacteroides bacteria. People from rural Africa tend to have more Prevotella bacteria. With all the advances regarding food, we are losing our ancestral microbiome due to changes in our dietary habits and surrounding environmental factors. This can have a negative effect on health, leading to diabetes development, colon cancer, I.B.D., all of them being more prevalent in the western world.
Prevotella bacteria
I hope you enjoyed this new introduction. Next post will be about community types.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
What is happening into Cryptoverse - 17.11.2020
Interesting end of the year, i must say, with a lot of surprising twists and turns in the Crypto-market. Let's see what happened lately!
BCH fork - it seems that Bitcoin Cash Node is the dominants one, being adopted by most of the main exchanges. Bitcoin cash ABC is freefalling, after they wanted to impose a 8% miner tax. Apparently people are not keen on having their rewards decreased.
A newly elected Republican senator, Cynthia Lummis, said ABC channel that she is seeing Bitcoin as a store of value. She started to be interested in Bitcoin in 2013.
More about Bitcoin, Grayscale bought another 241 million dollars of Bitcoin (15114 BTC) having a total of 506000 BTC (2.3% of the total market cap) at the moment.
Arya Stark (Games of Thrones well known assasin) is looking to add some Bitcoin to her portfolio. She was asking on twitter if she should **go long** for BTC.
Uniswap mass exodus - 40% of the liquidity moved out of the platform after they decided to stop the UNI rewards. Something needs to be done. Cooper Turley of Audius ( AUDIO) is trying to put a new governance proposal to be voted.
Origin protocol has been under attack, after a flash loan hacker got 7 million dollars worth of funds stolen. And i was thinking that **stolen** is just to be eaten on Chrismas DAI. https://www.coindesk.com/price/dai
Keep an eye of Sora. I wanted to buy it when it was 8 dollars, but i was thinking it is too expensive. Now, one month later, it is 107 dollars.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - what happen inside of us
The food that you consume is the one feeding your microbiome. Everything that cannot be digested by yourself it is used by your microbiome, which will transform all these indigestible components into energy that it is used by you.
Some beneficial microbes nibble on you eating the mucus produced by your body, as the human body will produce around 10 liters of mucus every day. The mucus is made of a protein backbone with chains of sugar molecules attached to it, known as mucus glycans. Some microbes adapted to eat these glycan structures produced by our body. These microbes are specialized in the consumption of the host-produced glycans, such as in mucus. Another type of glycans produced by the human body are the human milk oligosaccharides. The glycans in mucus and human milk are structurally alike, they are awkward sugars, rarely found in plants. This is why not many microbes can degrade these glycans.
The dietary glycan starch is a sugar chain of only glucose molecules, while primary sugars of mucus and milk glycans are n-acetilglucosamine, fucose, manose and sialic acid. Because these can be used by the microbiota, they are considered pre-biotic substances to nurture specific microorganisms (who serve a beneficial and protective role for the most).
The group of bacteria specialized in the degradation of the human milk oligosaccharides are known as bifidobacteria. In early life , bifidobacteria plays a role in energy harvest for the infant, they also play a crucial role in the immune and metabolic imprinting. Later in life, permanent colonization of the mucosal layer also leads to immune and metabolic regulation contributing to the host health. Because many pathogens use mucus as a signal to attack, the beneficial mucus colonizing microbiota members will protect against such pathogens. The host tolerates microbes in the mucosal layer and even produce extra mucus when sensing their presence. Another reason of existence of awkward sugars is that, if all bacteria will degrade the mucosal layer, this could be problematic.
Bifidobacteria
In conclusion, some microbiota members like eating the glycans from mucus and milk. Early life, they release energy from human milk, later in life they serve as a line of defense against pathogens. They also stimulate a healthy host immune and metabolic response. Our body will nurture specific members of the microbiota by producing special sugars.
Next post will be about long versus short dietary habits.
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - how disease and diet can affect our microbiome
Probably everyone knows that our microbiota is an anaerobic chamber with trillions of bacteria which work together and their combined efforts help us break down food and harvest as much energy as possible from the food we eat. Our microbiota depends a lot on the food we consume. In return, it will help us to digest the food we consume. Without the bacteria from our gut, the nutritional value of our food would be a lot lower (we would probably eat 5 times as much food to reach the same energy levels).
When microbes start to degrade the fibers from our food, this process is called fermentation. Microbial fermentation is a common process used to produce food (cheese, beer, bread etc.). All these foods have microorganisms added to them during the making process, leading to special taste or alcohol. Our microbiota also carries out a wide range of fermentation processes, using anaerobic fermentation in order to sustain the inner environment. The bacteria ca ferment both sugar and protein from our food, leading to the production of many chemicals with energetic value, essential vitamins and health stimulating products that are released in our guts by the microbiota. Many compounds are short chain fatty acids such as lactic acid, acetate, butyrate and propionate. All these short chain fatty acids are a major source of energy for our intestinal cells. Almost 10% of the energy used by our intestinal cells comes from the microbial produced butyrate. The butyrate and the propionate have several health benefits (pain reduction and inflammation response reduction).
Lactobacillus acidophilus
The microbiota is actually a microbial ecologic network, so, for optimal functionality, we need to have a microbial diverse microbiota. Our gut is an anaerobic chamber with trillions of bacteria working together and their combined effort helps us to break down food and to harvest as much energy as possible from the food we eat.
I will post next about mucus and milk fermentation.
See you soon!
Yours truly,
George
**P.S.** If you are Romanian, you can also publish your post in the **Publish0x Romanian Communit**y group for others to read it.
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - what happen as you get old?
When you age, your microbiota ages with you. Most significant changes in adult microbiota are caused by diet and medicine. After age of 65 hormone regulation changes, impacting energy levels, changing the physical activity, the smell, taste, feeling of fullness and satiety. Sometimes this can lead to a nutritionally imbalanced diet. Elderly people microbiota contains Proteobacteria (a group of bacteria with many potential pathogens) and because of this group, they are at higher risk of infections. Intestinal microbiota of older people is less diverse and has a compromised stability, making them vulnerable to infections and chronic diseases. Taking medicines can disturb the microbiota, but eating healthy and doing exercise helps to age graciously. Microbiota seems to play a role in healthy ageing, keeping immune system in check and protecting against pathogens.
At the moment 13 % of the world population is over 60 years old and this will only increase in the future. There are age-related diseases (cancer, diabetes type 2, atherosclerosis, insulin resistance etc.) and surprisingly many of them are associated with an alteration to the microbiota.
Is the microbiota composition changing with age? Let’s first define ageing as a continuous and progressive decrease of physiologic function across all organ systems. All these changes sometimes lead to different diseases. One of the most important effect in our case is the reduction of the gut motility as you get older. The changes in the microbiota follow the changes in the diet, physical activity patterns and other gut related physiological changes. As you get old, there is a decrease in the core gut microbiota (and we already know that the gut microbiota is a very important modulator of the immune system, being involved in ageing related low-grade inflammatory responses). Being an adult, the core microbiota is dominated by Ruminococcaceae, Lachnospiraceae and Bacteriodaceae. The older we get, the smaller the core microbiota becomes. For example semi-super centenarians (105–109 years old) microbiota will have a reduction of the core and an increase of the subdominant fraction (the sub-dominant fraction has many health-associated groups like Bifidobacteria, Akkermansia and Cristensenellaceae).
Lachnospiraceae
But overall there are not many researches related to the gut relation with healthy ageing, and the existent ones will consider the elderly age 60, 65 or even 70, so they are not using the same subcategories of people age segments.
Next post will be about centenarians and microbiota.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral* *1235256530* *for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - the antibiotics and the damage sustained after using it
Antibiotics are lifesaving in many cases. But for microbiota development antibiotics are a big threat. The transmission of microbiota from mother to infant provides the child with beneficial microbes. If the mother of the child has antibiotic treatment upon birth or right after, this will have devastating effect on the infant microbiome development. Because of this the child can have long lasting shifts in microbiota composition and metabolism, including the depletion of Bifidobacteria. Antibiotics are routinely administered during c-section, and this has a role in the delayed Bifidobacteria colonization. Bifidobacteria has been shown to be transmitted vertically from mother in case of normal birth. We have several long term effects if antibiotics treatment were prescribed early in life, such us the decrease in Bifidobacteria, increase in Firmicutes and Clostridial groups of bacteria, associated with the development and onset of allergic diseases. Perinatal antibiotic exposure and infant antibiotic use are also increasing the risk of allergies.
Firmicutes
Antibiotic induced disturbances of the microbial balance early in life can play a role in being overweight and obesity later in life (association between early life antibiotic exposure and childhood obesity has been observed in large cohort studies and is a certainty). Antibiotic usage in early life should be taken very seriously and consciously. The described association between microbiota, antibiotics and later life risks requires further investigation.
Next: Ageing and basic changes in microbiota.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
What is happenin' in the Cryptoverse - 13/11/2020
Bitcoin is 16.000 $. I repeat, 16k, it reached 16k. Not much until 20k. Keep going mate.
Ethereum did a scary thing yesterday, a bit late than Halloween. Some platform (like Binance, Metamask and Coinbase) had technical difficulties as apparently Ethereum had a hard fork due to a service provider, Infura, having a power outage affecting ETH mainnet API.
Due to a fast action and a complex and wonderful collaboration between many networks and cryptocurrency projects, Kucoin seems to have recovered almost 85% of the funds hacked last month.
MakerDao's DAI reached 1 billion dollars market cap. DAI is used for many projects lately, including League of Kingdoms blockchain game (using land as a NFT, and paying interest to the players in DAI). https://land.leagueofkingdoms.com?ref=LTPXMY
Bitcoin cash fork is near, even if the experts don't know yet if both forks will survive or one will be left to die.
DARMA capital is working on a ETH staking solution via LiquidStake, where you can also use your ETH as collateral for USDC loans.
DistrictOX increased 800% lately due to the Coinbase effect, after it was listed last week.
And, finally, somebody paid 111 thousand dollars on a digital F1 car. Wow, the moment when a NFT car cost more than a real one!
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - stages of development
Different developmental stages of the microbiota can be distinguished. The different developmental stages define the age of microbiota of a human being. Every increase or decrease in the microbiota age compared with the actual chronological age of a child can indicate various outcomes.
Firmicutes bacteria
After the first microbes colonize the human body, the microbiota start to develop, over the next few years, depending on environmental factors, like food intake. First change will happen during weaning, which starts a non random process of maturation, induced by the change of the nutrient consumption. During the first phase of milk consumption we have Bifidobacteria as a dominant member of microbiome. Upon weaning, members of Firmicutes and Bacteroidetes become dominant. Microbiota reaches adult stage in 3–6 years, being fully maturated after puberty. Main markers of bacterial adulthood are already present at toddlers. The microbiota of formula fed babies is more mature compared to a breastfed child. The maturation of microbiota also happen faster at c-section born babies.
Maturation of the microbiota is directed by nutrition. Malnutrition in early stages of life can result in irreversible stunted growth and impaired cognitive ability. The microbiota of malnourished children does not mature fully. But a food intervention rescuing children from malnutrition will immediately mature the microbiota. The potential relationship between infant malnutrition and gut microbiota might contribute to food and microbial based therapies for malnourished people. Microbiota -modulation strategies could help restore infant growth and developmental problems. Increase or decrease of microbiota age in comparison with chronological age of the child can be used to find different health outcomes. Immature microbiota is associated with malnutrition, while faster maturation is associated with formula feeding and c-section birth. Because of all these reasons, microbiota-modulation can be the next-step strategy supporting personalized nutrition and microbiota based strategies.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Once upon a time in Cryptoverse - 12/11/2020
Monero was hit in the past 11 days, by a Sybil attack trying to destroy the network reputation using a number of pseudoanonimous identities, but the developers declared the attacker 'incompetent', as the recent updates were crucial in making the network resilient versus this kind of attack. Government much?
Bayern Munchen joined Sorare fantasy football blockchain game, with limited edition trading cards.
Ethereum 2.0 deposit contract has more than 22 million dollars after it was launched one week ago.
Shapeshift was forced by US regulators to delist Monero, Dash and Zcash.
Lebanon is the next country to announce a digital national currency to be launched next spring.
Uniswap liquidity mining program is scheduled to finish on November 17, after it was pushed out from the initial date on November 12.
Binance volume traded in October decreased with 33%, compared to September, and Huobi dropped by 31%, followed by Okex with 42% (Okex had some internal problems, leading to a total withdrawal stop, apparently under pressure from the Chinese Comunist Party).
Loopring (LRC) is on the roll lately, with more than 28% increase, the second day in a row.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Tron hack or developer error? What happened in there?
There is a incessant rumour on Twitter about Tron network being hacked. Let's investigate what really happen.
First it is this rather intriguing Tweet:
https://twitter.com/TruthRaiderHQ/status/1323170437656940545
What we found out? During the 4.1 version upgrade period, the TRON Mainnet was attacked by a malicious contract on 2020.11.02 at 06:14 (HKT). The attack initiated malicious transactions, causing the super representatives to stop producing new blocks. It was something to do with getting a profit from the network, while it was stopped. I am thinking that he may wanted to create a sidechain, and to continue to mint ghost TRX and sell it. But i may be wrong. However, after almost 2 hours, at 8.29, Tron network resumed its activity and started to produce new blocks, once again. By 9.40, the whole network was back to normal. Justin Sun was happy to declare that all the funds are safe and i quote (please do not laugh too much):
''Withstand this large-scale attack, once again proving that the #TRON network is the decentralized network with the most resilience and attack defense capabilities in the industry!'' (Justin Sun - 3.11.2020) https://twitter.com/hashtag/TRON?src=hashtag_click
Now not too much details were given about what really happen, except that the data on the chain is intact and the user assets are safe. But the response was quick and the danger was contained. Even if all this happened, TRX token price still went down from $0.0258 to $0.0246, which is around 3-4%.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - a newborn journey into the world
Did you ever ask yourself how the microbes enter in your body? Your mom donated many of her beneficial microbes during birth, and she fostered the growth of you and your microbes with her milk, providing nutrients for both you and your microbiota. If you are born by cesarean section your microbiota will develop differently, and this can be linked to later life diseases like allergies and obesity. As an infant, your microbiota was very different, and growing up, it grew up with you. First time receiving solid food was a life changing event for both you and your microbiome.
Lactobacillus plantarum
Each individual has various habitats of microbial communities. The human body is continuously sampling the pool of available environmental microbes. A selection take place for specific microbes that will find their optimal niche in our different body organs. The microbial colonization of humans was thought to begin at birth, but there is evidence of bacterial presence in the placenta, umbilical cord and amniotic fluid of healthy full term pregnancies. This means that microbial exposure started before delivery, allowing the fetus to adapt to microbiota and stimulating the perinatal immune system. Upon and right after the birth a massive amount of microbes enters in contact with the newborn. The colonization of the body by the microbes is influenced by the mode of delivery, type of feeding and/or antibiotic usage. Mothers diet, age and metabolic status, combined with the family genetics and lifestyle are also affecting the infant microbiota development. The colonization it happens vertical (during birth, with microbes from mother lower intestinal tract and vagina) and horizontal (after birth, close contact with siblings, pets, dietary habits). Once the microbes enter in the human body, the conditions of the different body parts are determining which microbes will remain for colonization. The microbiota composition of the stomach, duodenum, ileum and colon are quite different. Acidity, transfer time and nutrients absorption are few of the important factors to select which microbes will adapt to each condition. For example, in the ileum we have a fast transit time (2–6 hours), a thin layer of mucus and the host is continuously absorbing proteins and sugars, so this conditions are sub-optimal for most of the microorganisms. In the colon is a complete other situation, with a transit time of 24–48 hours, thick mucus layer and many non digested fibers are available to microbes to ferment. This is the reason why the colon is the most densely microbial populated part of human body (10–12th bacteria per gram of feces, about 1 kg of mass in total).
Right after birth, the gastrointestinal tract is getting colonized first with facultative anaerobic bacteria, which will reduce the oxygen level in the intestine, making it easy for the anaerobic bacteria to survive. This step it will take 1–2 days to complete. The early life microbiota is dynamic, unstable and a significant variation exists between babies. But this is a non-random process, the body selecting the microbes that have adapted to the conditions of the different organs. The exposure to microbes is mainly determined by the more od delivery, type of feeding and antibiotic usage.
Next post will be about the importance of human milk.
A very interesting post about a vulnerability on Bitcoin SV. I wonder how this problem is solved on BCH.
https://www.publish0x.com/crypto-markets-and-marginal-gains/warning-bitcoin-sv-vulnerability-making-your-wallet-prone-to-xqoxvry
Microbiota - Cause and effect
Clinicians and biologists try to find correlations between the gut microbioma and health outcomes. Very often no causal link is found. If one is ill for long time, chances are that medications were used regularly, and if one is obese, chances are that he/she ate unhealthy for long time. These factors will influence the onset of the disease and the gut microbioma composition. Even more, other factors like country of origin and the genetic background will also play a role in the gut microbiome composition and in the chance of developing certain diseases. The main challenge is to find out the right changes in the gut microbiome that actually play a role in the disease. Is then the fact that, in a dataset of thousand of bacteria, some of them show a correlation with the disease real or based on sheer coincidence?
Akkermansia Muciniphila
A good example of causal relationship between the gut microbiota composition and the development of a disease is fecal macrobiota transplantation. This strategy was applied for patients with Clostridium difficile infections and the results were good, as this microorganism is able to thrive in people with disturbances in their gut microbioma, but a fecal transplant of a healthy gut microbiome composition will restore the balance and get rid of C.difficile bacteria. Another interesting development in the study of the healthy microbiome shows that the bacterium Akkermansia Muciniphila is abundant in healthy people but often absent or low in human or mice with obesity. If you feed them with A. muciniphila, a relation between the bacteria and the metabolic health of the host is noted, and a positive effect on health balance and metabolic rate. An ongoing clinical trial with pre-diabetic patients is done right now in order to confirm those positive effects.
Other option to study causal relations between gut microbiome and health can happen in laboratory, using germ free mice, and exposing them to specific bacteria to test the effect on metabolism, digestion or immune system. But we cannot have a decisive answer using these methods, and a clinical trial using an appropriate group of patients is always needed, hopefully resulting in personalized treatments against diseases, taking into account the differences in our microbiome.
Microbiota is defined as everything staying in our gut, small enough to not be seen with naked eye (bacteria, archaea, fungi and viruses) and their habitat. Microbes form our gut play a role in all kind of systems to good liver access, good brain access, good skin access. The microbiota is personalized, everybody has a different microbiome. Monozygotic twins are more similar than average unrelated individuals in terms of microbiome, and this can be because genetics or same time colonization. The microbiome develops through life, so some of our actions will impact later in life (as repeated use of antibiotics for example). We have an enormous number of associations between our microbes and our cells activities, but no casualty (the famous example with recurrent C. difficile patient in intensive care and almost dying being rescued by fecal microbiota transportation in a systematic way, much better than antibiotics).
We got MetaHit project, with over 3 millions genes discovered in the guts of a couple of people, aiming to understand what is it there in our microbiota, but also what is their function, how they are expressed, how they are collaborating and constituting this ecosystem that makes us healthy. There is a symbiosis relationship (Venom is a great movie about symbiosis, by the way) and we feed the microbes that we want to have in our gut. As important hallmark of our discoveries in the last couple of decades, Akkermansia Muciniphila (the gatekeeper of mucus) reinforces our gut barrier and prevents substances like LPS to come into our bloodstream.
In the next posts i will talk about the early life microbiota development.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - The OMICS techniques
OMICS approaches stand for collective characterization and quantification of pools of biological molecules. A gram of feces contains 10 to 12th of microbes. Not all of them are the same, with some of them being present in higher quantities and other in lower quantities. If you visualize them as a ping-pong balls, 10 to 12th of the room is occupied by them balls, each of them of different colors, each color representing a microbial species. If you pick 10 balls, you cannot have an accurate representation of the composition, but if you pick one million, you can be close to it.
OMICS techniques in microbiome research are doing that. By taking a sample and analyzing, you can get a snapshot of the composition at a certain point. The most widely used technique to study the microbiome is **16s rRNA DNA profiling**, and by using primers to amplify the 16s rRNA gene of all microbes, you can create a database of DNA sequences. From one fecal sample, you can generate 1000 to 1000000 of 16s DNA sequences. The microbe most abundant in the sample will be found back the most in terms of 16s DNA sequence reads, the microbes that are not very abundant will be not detected or will generate only few of those 16s DNA sequences. This can be used to find out what microbes are there, what microbes are well represented and what microbes are present in low numbers.
To study the genetic potential of the microbiome we can use the information of the complete genomes of all microbes in the fecal sample. This technique is called **metagenomics**, where a set of primers is used to amplify any gene of the microorganism, in this case all the ping-pong balls are colored by gene, with many more different colors. After sequencing, a database of DNA is generated, that can hold again millions of reads. The reads can be grouped in batches, depending on the information you are interested like in batches of similar genes, for example. This way you could tell how much antibiotic genes are present in the microbiome. Another advantage of metagenomics is that the genes can be used to assemble genomes. This way you can extrapolate complete genomes from your fecal sample. This also makes it possible to discover complete genomes of bacteria that are not yet cultured. The genome information could be used again to understand what a microbe needs for its physiology, and this information can help to design a culture media for an uncultured microbiota member.
Another approach is used with **metagenomic databases**, to compare set of genes of microbiome between groups of individuals. This way differences in microbiota composition can be taken to the next level, you can compare health individuals with ones having diabetes and see the difference, for example. This can help to understand the functional role of the microbiome in states of disease. The creation of big microbial databases products, by sequencing DNA, RNA, proteins and metabolites, can be done if needed.
Each of this different approaches can give us clues about the function of microbiota, it will tell you what is the most abundant microbe and what are the differences between samples. But we do not need to forget that the generated results are just predictions based of a snapshot of a certain sampling moment. OMICS approaches are techniques that generate big databases of molecular data and are a big advantage in culture independent studies of the microbiome.
Next post will be about microbiome research and causality.
Have a nice day!
G.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Microbiota - the history behind it
In 1665 Robert Hooke and Anton Van Leeuwenhoek discovered the existence of tiny microorganism using microscope magnifying x 25 to x 250 . The microscope was used to understand microbes. Much later other techniques were discovered, such as culturing (the isolation of a specific type of bacteria which will grow on a specific media that supports its growth). Culturing will enable you to find out how does it look like and what does it produce, and to test its sensibility to certain antibiotics. Not all bacteria can be cultured yet, as , as we do not know what certain microbes need to grow. , From the human macrobiome, we are able to culture only 30%. Today culture independent techniques are used to study the microbiome, making use of the DNA, proteins and/or metabolites from the microbiota to understand what microbes are there and what they are capable of doing. A fecal sample can tell you how your microbiota is interacting with your body and ( using informations from proteins and metabolites). You can find out about your food digestion and vitamin production of your microbiome. One of the most used techniques to find out what microbe we deal with is the one using the 16s rRNA gene, a gene found in bacteria and archaea, but missing in humans and other eukaryotes. It has a conserved region that is common to all bacteria and a variable part, specific to every species, and can be used to tell species apart. Using 16s rRNA gene, we can find out which bacteria is present in the sample. Using culture in dependent molecular approaches we can see what they are doing in our bodies.
Another more important group of techniques are known as Omics Techniques. We will find more about these in the next blog post.
Wish you a nice day!
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
The human Microbiome (intestinal friendly microbes)
Today I will start a new series of articles, talking about our microbiome, or in layman terms, our gut intestinal flora — the microbes living inside of us and how they are actively helping us. It is an interesting subjects, and the latest researches seems to just start to discover how important is our relation with our nonpathogenic bacteria and microbes.
These days we keep hearing different opinions about this elusive thing called microbiome. What is that and how it can help us? You are in the right place to find out, through my next series of blog posts about it.
Every human microbiome is different and it is continuously changing during the course of one's life. Many factors play a role in the development of the human microbiome. Even early life events, like mode of delivery and gestational age at birth can play a role in seeding and shaping the microbes that colonize the gastrointestinal tract. Later in life there are also changes in the macrobiome, correlated with the ageing process. Dietary habits impact on the microbiome, and diet related diseases such as obesity and metabolic syndrome will influence it. Effects of the short term dietary changes will be analyzed too.
There are many benefits coming from our microbiome, as microbes digest food components, produce some of the vitamins ( K, B12 ) and stimulate our immune system. Our entire body is colonized by microbes, and those microbes are actually keeping us healthy. They protect against pathogens (microbes that make us ill), by simply taking up the space, preventing colonization by other microbes. A system without microbes is very vulnerable to infectious microorganisms (we are talking here about newborns and germ-free pets). Having a healthy microbiome will stimulate our immune system, as a healthy immune system needs to be exposed to different microbes and compounds and find out what is harmless and what can cause a disease, other way it cannot maturate. If the immune system is not mature, it can turn its attention to non-pathogenic substances, attacking them. Turning against food particles, it can cause allergies. Turning against own body, it can cause auto-immune diseases like multiple sclerosis or diabetes type 1. Working in the right way, the immune system will be on symbiosis with the macrobiota, a mutual helping alliance that helps the immune system to figure out which microbes and particles are trustworthy and which are not. The microbiota also produces some substances that can influence our metabolism, our feeling of hunger and our weight gain or weight loss. The digestion of fiber by our microbes leads to secondary products that our body can use as an energy source (they increase the energy yield from our food, so we need to eat less). The microbiome can produce vitamins that we absorb and use (vitamin B complex and vitamin K).
At the moment we wash our hands a lot, sometime using soap that kill 99.99% of bacteria, we eat meat that was previously treated with potent antibiotics or we use antibiotics directly, and in doing this, we kill the pathogens, but we also kill a part of our "friendly" microbes. We strongly suggest to check the products you use to see if they contain any antibiotics, as excessive and unnecessary use of it, especially at young age, can lead to obesity risk, diabetes type 2 and auto-immune diseases. There are many other diseases linked to the macrobiome disruption. There is a hygiene hypothesis stating that lack of early childhood exposure to all kind of microbes, infectious agents and parasites will suppress the natural development of our immune system.
Next post: Microbiome study
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Essential supplements - Ginseng
This is the last article of the series. I will start another one soon if i have time about microbiota - our intestinal flora.
We have 2 different kind of Ginseng — The Asian one (Panax Ginseng) and the American one (Panax Quinquefolius). Both of them are supposed to boost energy, lower blood sugar, lower cholesterol levels, reduce stress, promote relaxation, help in diabetes treatment and with sexual dysfunction for men. The chemical components found in Ginseng, ginsenosides, are responsible for the clinical effect of the herb.
Benefits:
may help stimulate physical and mental activity in people who feel tired (good results in helping cancer patients undergoing treatment with fatigue);
may improve thinking process and cognition;
the ginsenosides have anti-inflammatory effects;
can treat erectile dysfunction;
there is a link between ginseng and the treatment and prevention of influenza and respiratory syncytial virus;
may help lower blood sugar and help treat diabetes as it is improving the insulin resistance;
increase the general well-being of the one using it.
Side effects:
it is safe to consume but may give headaches, sleep problems, edema, diarrhea, dry mouth and can make changes in the blood pressure and the blood sugar level;
do not mix with antidepressants (MAOIs class), heart medication, blood thinners (warfarin, aspirin);
may increase the effect of caffeine;
can cancel the effect of the painkillers like morphine.
Dosage:
the recommended dose is 200–400 mg per day, but it is bio-active from a dose of 40 mg per day.
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
Essential supplements - Ginkgo biloba
Ginkgo Biloba, also known as Maidenhair, is a living fossil, used in traditional Chinese medicine (seeds and leaves). Today we use Ginkgo extract, made from the leaves.
Benefits:
contains high levels of flavonoids and terpenoids (both of them powerful antioxidants fighting the damaging effects of the free radicals — anti-ageing;
has the ability to reduce inflammation caused by various conditions;
can increase the blood flow dilating the blood vessels, helps with poor circulation;
might help in some cases of Alzheimer’s and other forms of dementia, especially if it is used alongside the conventional treatment;
may improve mental performance in healthy people;
may help to treat anxiety and had the potential to treat depression;
may be effective for some types of headaches;
may help with respiratory diseases due to its anti-inflammatory effects;
may reduce PMS symptoms;
may improve symptoms of sexual dysfunction.
Side effects:
do not use in case of allergy to alkylphenols;
can increase the risk of bleeding (do not mix with warfarin, aspirin, prozac, zoloft, ibuprofen and tylenol);
to some people can induce dizziness, headaches, nausea.
Dosage:
120–140 mg divined into several doses during the day (effects can be noticed after at least six weeks).
That's all for today
Yours truly,
George
*Why not...*
*...have fun and win rewards on blockchain games (**Splinterlands* *- Hearthstone-like card game) (**Axie Infinity* *- NFT battle)* https://splinterlands.com/?ref=mightyrocklee https://land.axieinfinity.com/purchase?r=sBisOZSRuTIKRWrQ5pbSAytrrdM
*...use the* ***world best cryptocurrency exchanges****:* *Binance**,* *Coinbase* *and* *Kucoin**.* https://www.binance.com/en/register?ref=L05S7B12 https://www.coinbase.com/join/gmihalache https://www.kucoin.com/ucenter/signup?rcode=7xfryf
*...get the higher rewards for your* ***investments*** *using* *Blockfi* *and* *Celsius.network**, use referral 1235256530 for $20 bonus.* https://blockfi.com/?ref=8cff0fb6 https://celsius.network/get-the-app/?_branch_match_id=786176267473301667
*The* ***most lucrative faucets*** *that I use:* *ZEN**,* *ZEC**,* *PIVX**,* *LTC* *and few others.* https://getzen.cash/auth/register?ref=257678 https://globalhive.io/auth/register?ref=1920 https://pipeflare.io/r/1004 https://www.thecryptofaucet.com/?r=61485
*Get* ***ETH*** *while writing on* *Publish0x* *blog, using the* *Brave* *browser -* *Presearch* *search engine to maximize your* ***BAT*** *income.* https://www.publish0x.com/?a=y5eVGmvaEP https://brave.com/geo707 https://www.presearch.org/signup?rid=1685676
*Check my Lbry.tv* *channel* *in here. I am also writing on* *Read.cash* *(Bitcoin Cash rewards there).* https://lbry.tv/$/invite/@Crypto_I_tested_it_so_you_didn't_need_to...:b https://read.cash/r/Heruvim78
*Disclaimer: This text also can be re-published on my personal blogs, such as* *this one**.* https://oneurbanfairytale.blogspot.com/2020/05/tests-and-pathways-leading-to-early.html
@Heruvim78