Developmental dyscalculia may be a specific learning difficulty which reflects deficits in arithmetical skills. The cause behind this disorder isn't known. Recent studies provide evidence in favor of believing that the disorder is somehow tied with specific brain regions’ roles. These regions include the intraparietal sulcus (IPS), the angular gyrus (ANG) and therefore the supramarginal gyrus (SMG) in developmental dyscalculia. this study investigates the role of those regions in adults with developmental dyscalculia. Brain images were collected from 10 participants with developmental dyscalculia and 10 control participants using fMRI while conducting number comparison, multiplication and subtraction tasks. The results revealed the activation of the intraparietal sulcus during number comparison and therefore the activation of both the angular gyrus, the supramarginal gyrus, and therefore the intraparietal sulcus during calculation tasks. These results suggest that the IPS activation wasn't but the developmental dyscalculia group than within the control group when conducting the amount comparison task; which there have been activation within the ANG, SMG and IPS regions of the brain in participants’ brains during both the multiplication and subtraction tasks.