Introduction:
The synthetic and natural based polymer are used in pharmaceutical and biomedical industry and their application are growing so fast way. Understanding the role of polymer as ingredients in drug product is important for pharmacist and also pharmaceutical chemist.
1. polymer in Drug Delivery
Pharmaceuticalpolymersarewidelyusedtoachievetastemasking;controlledrelease(e.g.,extended, pulsatile, andtargeted) enhancedstability andimproved bioavailability.
Mono lithic delivery devices are systems in which adrug is dispersed within a polymer.matrix and released by diffusion.The rate of the drug release from amatrix product depends on the initial drug concentrationan relaxation of thevpoly-merchains,which overall displays a sustained release characteristic.Extended release alprazola mtabletisane in which extended or sustained delivery is provided by swelling and erosion of the polymermatrix.
Characteristics of Ideal polymer
low density
low coefficient of friction
Good corrosion Resistance
Good mould ability
Economical
poor tensile strength
poor temperature Resistance
General Mechanism of Drug Release
There are three Mechanism of drug release;
Diffusion
Degradation
water penetration
