Barcelona will host Real Sociedad in Week 19 of La Liga on Wednesday.
Barcelona captain Lionel Messi is one of 22 players named in Ronald Koeman's squad for the Camp Nou clash.
Argentina captain Messi will either overturn or erase Pele's all-time goalscoring record.
Former Brazil international Pele has scored 643 goals in his 19 seasons at Santos, the most by any club in the 50-year-old era.
Messi has scored 642 goals in 17 seasons for Barcelona, in 746 games and has conceded 278 goals.
Sociedad's Mikel Oyarzabal is also top of La Liga with seven goals, but will miss the match against Barcelona due to injury.
Messi has scored five goals and conceded two penalties in La Liga this season.
Messi scored 14 goals for Sociedad
Messi has scored 14 goals in 21 appearances for Real Sociedad in his career.
Before the onset of coronary heart disease, Messi scored against Sociedad in Barcelona's 1-0 win in March.
Barcelona's match against Sociedad will give Messi a one-goal lead against Pele.
He also managed to become the top scorer in La Liga this season, and the victory will give the club a top spot in La Liga.