Evaluation of platelet indices in patients with nephrotic syndrome Entry Nephrotic syndrome (NS) proteinuria, with hypoalbuminemia, hyperlipidemia, and edema a common glomerular is a disease. Complement in nephrotic syndrome activation, circulating permeability presence of factors, anti-inflammatory benefit from treatments, NS important role of inflammation in the pathogenesis of It shows you playing. 1 Platelet activation of markers in NS variety that can be used to show demonstrated in studies. thrombocytosis, It is a common finding in NS. in 2 NS platelets are hyperagreable shown. 3 Indicating inflammation platelet markers, activation of NS and guide in predicting the prognosis it could be. Mean platelet volume (MPV), platelet distribution width (PDW), platelet count (PCT), platelet count (PLT), and platelet large-cell ratio (P-LCR) indicates platelet activation and complete automatically reported in the blood count. 4 MPV platelet volume, PDW circulating shape differences in platelets, PCT is a platelet count in unit blood volume (marker showing total platelet volume) and corresponds to hematocrit in erythrocytes)5 and P-LCR is normal for large platelets. shows the ratio of platelets to platelets. Large platelets are more reactive and dyslipidemia to vaso-occlusive events in patients with contributes. 6 In this study, thrombocyte indexes as a marker in NS determine whether to use intended. Methods From January 2017 to January 2018 to the Pediatric Nephrology Outpatient Clinic in our center. All patients followed up with the diagnosis of NS presenting were included in the study (N=39). Study Compliant with the Principles of the Declaration of Helsinki It was performed as a clinic in our center. by the Research Ethics Committee approved. Studying patients with infections was excluded. Hemoglobin (HGB), hematocrit (HCT), Mean erythrocyte volume (MCV), Red sphere distribution width (RDW), White blood cells (WBC), PLT, MPV, PDW, PCT, PLCR, urea, creatinine, electrolytes, albumin,cholesterol, triglyceride, urinary findings in relapses and remissions of the disease obtained from the records. Working group steroid-sensitive NS (SSNS) and steroid-sensitive resistant NS (SRNS) into two groups. Left. Patients in both groups relapsed laboratory before treatment values ​​are compatible with both age and gender. with the healthy control group as well as with each other. were compared (N=30). In the SSNS group values ​​before and after steroid therapy compared to steroid therapy effect on platelet indices researched. Platelet indices hematological on analyzer (Sysmax, XN-1000, SA-01, Japan) using flow cytometric methods. measured. Blood samples taken from patients analyzed within hours. Platelets methodological evaluation of the indexes reference values ​​as a result of problems difficulties arise in determining can come out. 7 With a healthy control group this difficulty by comparing the patient group has been eliminated. Nephrotic syndrome diagnosis hypoalbuminemia (albumin<2.5 g/dl), nephrotic level proteinuria (40 mg/m2/h), was placed in the presence of hyperlipidemia and edema. Remission in nephrotic syndrome, urine <4 Proteinuria below mg/m2/hr or spot urinary protein/creatinine ratio <0.2 defined as being. SSNS, 4-8 weeks daily (2mg/kg/g) prednisolone patient in remission after treatment group, while the SRNS group steroid therapy at the same dose at the same time group of patients who did not go into remission after was defined as. Renal biopsy 1-10 age, without hypertension, normal kidney function and complement good response to steroid therapy minimal change disease It was not made considering the pre-diagnosis. SRNS kidney for all patients biopsy was performed. Statistical analysis Normality of continuous measurements controls were tested with the Shapiro Wilk test. Control and individuals with nephrotic syndrome for differences in continuous measurements Student's t test was used. control, steroid resistant and steroid-sensitive nephrotic pertaining to continuous measurements in individuals with the syndrome Variance analysis to detect differences used. Homogeneity of variances controls were tested with the Levene test and differences between groups in homogeneous Heterogeneous with One Way ANOVA test Tested with the Welch test. Dual For comparisons, the Bonferronni test and Games-Howell tests were used. Descriptive mean and standard as statistics deviation values ​​are given. Categorical If the dependency between the variables is Tested with the Pearson Chi-Square test. Number and percentage as descriptive statistics values ​​are given. As statistical significance p<0.05 was taken.